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CCL20 antibody | O03-3H12

Mouse anti Human CCL20:Biotin

Product Type
Monoclonal Antibody
Clone
O03-3H12
Isotype
IgG1
Specificity
CCL20

Product Code Applications Pack Size List Price Your Price Qty
MCA6203B
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E 0.1 mg loader
List Price Your Price
loader

Mouse anti Human CCL20 antibody, clone O03-3H12, recognizes C-C motif chemokine 20, also known as LARC, MIP3A, and SCYA20. The chemokine CCL20 is expressed mostly in the lymphatic tissue, lung, and liver, and is produced by cells involved with the inflammatory and immune responses. CCL20 plays an important role in recruiting inflammatory cells to the site of infection or injury (Soto et al. 2017). However, CCL20 is involved with pathogenesis of chronic inflammatory disorders, specifically interstitial lung fibrosis and chronic obstructive pulmonary disease (COPD), and can contribute to tumor metastasis (Zhang et al. 2017). Inhibition of CCL20, along with its ligand CCR6, might have valuable therapeutic potential for treatment of autoimmune and inflammatory diseases, and is therefore a target of interest for drug discovery (Ranasinghe and Eri 2018).

The biotinylated Mouse anti Human CCL20 antibody, clone O03-3H12 (MCA6203B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL20 antibody, clone J03-4D4 (MCA6202GA) as the capture antibody.

Target Species
Human
Product Form
Purified IgG conjugated to Biotin - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% Sodium Azide (NaN3)
1% Bovine Serum Albumin
Immunogen
E. coli derived recombinant human full length CCL20 (Ala27-Met96)
Approx. Protein Concentrations
IgG concentration 0.1 mg/ml
Fusion Partners
Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
ELISA Matched Pair(s)
ELISA Matched Pair-Capture Antibody: MCA6202GA
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA 1.0 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Description Product Code Applications Pack Size List Price Your Price Quantity
Mouse anti Human CCL20 MCA6202GA E 0.1 mg loader
List Price Your Price
loader
Description Mouse anti Human CCL20

Synonyms
MIP-3a
UniProt
P78556
Entrez Gene
CCL20
GO Terms
GO:0042742 defense response to bacterium
GO:0007165 signal transduction
GO:0005615 extracellular space
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007267 cell-cell signaling
GO:0008009 chemokine activity

MCA6203B

100005093

If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.

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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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